Pullamsetti’s lab is focused on understanding how epigenetic mechanisms and transcription factors impact gene regulation so that this information can potentially be used to develop new therapeutic strategies for lung diseases.

Lung Research

Respiratory diseases are leading causes of death and disability in the world.

Globally, four million people die prematurely from chronic respiratory diseases that includes lung cancer, chronic obstructive pulmonary disease (COPD), asthma, occupational lung diseases and pulmonary hypertension (PH).

News Updates

Pullamsetti lab received 2.5 million Euro for two projects funded by the German Federal Ministry of Education and Research (BMBF) for the longitudinal epigenetic studies of COVID-19 samples from NAPKON (National Pandemic Cohort Network) study platform.

https://dzl.de/news/bmbf-foerdert-zwei-forschungsprojekte-des-dzl-zum-thema-long-covid-2/

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news img In a collaborative study, Pullamsetti and Goncharova labs described a novel pro-proliferative role of MST1/2 in pulmonary hypertensive (PH) pulmonary vasculature, providing a novel mechanistic link from MST1/2 via BUB3 and FoxO to the abnormal proliferation and survival of pulmonary vascular cells and thereby to vascular remodeling, suggestings new target pathways for therapeutic intervention.

https://pubmed.ncbi.nlm.nih.gov/35124974/

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news img In an extensive epigenetics-wide study Pullamsetti lab uncovered the epigenetic changes linked to the reexpression of developmental TFs (TBX4, TBX5, and SOX9) in adult PAH-FBs that are comparable to the expression signatures identified in fetal lung mesenchyme. The study shows that this proteins were elevated in the newborn PH and were strongly reexpressed in the vasculature of pediatric and adult PAH patients, while their pharmacological inhibition reduces the remodeling of distal pulmonary vessels, improves hemodynamics, and reverses the established PAH in three rodent models in vivo, enabling the development of new therapeutic strategies for PH.

https://www.science.org/doi/abs/10.1126/scitranslmed.abe5407